FDA Warning Letter
Dear Mr. Kirsch: This letter objects to Cephalon Inc’s (Cephalon) dissemination of false or misleading promotional materials1 for…
February 20, 2023
Month: June 2020
A Double-Blind, Placebo-Controlled Investigation of the Efficacy of Modafinil for Sustaining the Alertness and Performance of Aviators: a Helicopter Simulator Study
ABSTRACT RATIONALE: In 1998, the FDA approved modafinil for treating excessive daytime sleepiness in narcoleptics, and this…
February 20, 2023
Wake-Promoting and Sleep-Suppressing Actions of Hypocretin (Orexin): Basal Forebrain Sites of Action
ABSTRACT The hypocretins (orexins) are a newly identified peptide family comprised of two peptides, hypocretin-1 and hypocretin-2….
February 2, 2023
The Vigilance Promoting Drug Modafinil Increases Extracellular Glutamate Levels in the Medial Preoptic area and the Posterior Hypothalamus of the Conscious Rat: Prevention by Local GABAA Receptor Blockade
ABSTRACT The effects of modafinil on glutamatergic and GABAergic transmission in the rat medial preoptic area (MPA)…
February 20, 2023
Effects of Modafinil on Working Memory Processes in Humans
ABSTRACT RATIONALE: Modafinil is a well-tolerated psychostimulant drug with low addictive potential that is used to treat…
February 2, 2023
Modafinil : A Review of Its Use in Excessive Sleepiness Associated with Obstructive Sleep Apnoea/Hypopnoea Syndrome and Shift Work Sleep Disorder
ABSTRACT Modafinil (Provigil((R))) is a wake-promoting agent that is pharmacologically distinct from CNS stimulants, such as amfetamine,…
February 2, 2023
Pills Provide Brain Boost for Academics
Some academics use ‘smart drugs’ to sharpen their performance. Tony Tysome explores the issues Feeling under intense…
February 2, 2023
Central Alpha 1-Adrenergic Stimulation in Relation to the Behaviour Stimulating Effect of Modafinil; Studies with Experimental Animals
ABSTRACT Single administration of the new drug modafinil was followed by an increase in locomotor activity in…
February 2, 2023
Modafinil Improves Cognition and Attentional Set Shifting in Patients with Chronic Schizophrenia
ABSTRACT Modafinil, a novel cognitive enhancer, selectively improves neuropsychological task performance in healthy volunteers and adult patients…
February 2, 2023
Wakefulness Finds a Powerful Ally
Laurie Coots, a marketing executive who flies to meetings in other countries twice a week, spent years…
February 20, 2023