Modafinil decreases food intake in humans subjected to simulated shift work
by
Perez GA, Haney M, Foltin RW, Hart CL.
Division on Substance Abuse,
New York State Psychiatric Institute and Department of Psychiatry,
College of Physicians and Surgeons of Columbia University, USA.
Pharmacol Biochem Behav. 2008 Jun 4.


ABSTRACT

In a limited number of studies modafinil has been shown to decrease food intake by laboratory animals and humans. The present study represents a secondary data analysis, in which the effects of modafinil on several measures of food intake were determined in humans living in a residential laboratory during simulated shift work. During this 23-day study, a wide selection of food items and beverages were freely available. During this double-blind, within-participant study, volunteers (N=11) received oral modafinil dose (0, 200, or 400 mg) 1 h after waking for three consecutive days under two shift conditions: day shift and night shift. Shifts alternated three times during the study, and shift conditions were separated by an "off" day. Modafinil (200, 400 mg) dose-dependently decreased total caloric intake by ~18% and ~38%, respectively, regardless of shift condition, without selectively altering the proportion of total calories derived from carbohydrate, fat and protein. Ratings of "Hungry" were also significantly decreased by both active doses, but only immediately before the lunch break period. In addition, tolerance to the anorexic effects of modafinil was not apparent, as these effects remained stable across the three days of modafinil dosing. These findings show that modafinil produced clear reductions in food intake and suggest that future prospective studies should examine the drug in obese participants.


Mood
Orexins
Serotonin
Dopamine
Glutamate
The sleep-switch
Modafinil: structure
Atypical depression
Modafinil and the aviator
Modafinil: pharmacokinetics
Modafinil and the marmoset
Modafinil wakes up sleepy flies
Modafinil versus amphetamine
Modafinil versus methylphenidate
Modafinil v amphetamine v placebo
Fatigue, sleepiness in major depression
Modafinil plus SSRIs for depression and fatigue
Dosing regimen effects of modafinil in narcolepsy
Mood-lifting effect of caloric restriction is mediated by orexin
Modafinil plus selective serotonin reuptake inhibitors (SSRIs)
Modafinil: a dual noradrenergic-dopaminergic mechanism of action?


Refs
and further reading

Purchase Modafinil

HOME
HedWeb
Nootropics
erythroxylum-coca.com
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Good Drug Guide

The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family