Modafinil increases histamine release
in the anterior hypothalamus of rats

by
Ishizuka T, Sakamoto Y, Sakurai T, Yamatodani A.
Department of Medical Physics,
School of Allied Health Sciences,
Faculty of Medicine,
Osaka University,
1-7 Yamadaoka, Suita,
565-0871, Osaka, Japan.
Neurosci Lett 2003 Mar 20;339(2):143-6


ABSTRACT

Modafinil, (RS)-2-(Diphenylmethylsulfinyl)acetamide, is a well known wake promoting drug used for the treatment of narcolepsy. We investigated the effect of modafinil on the hypothalamic histamine release in the anesthetized rat using in vivo microdialysis. Modafinil (150 mg/kg, i.p.) increased histamine release by 150% of the basal release. The intracerebroventricular (i.c.v.) injection of modafinil (1 nmol) also increased histamine release, however, when modafinil (1 nmol) was injected directly into the tuberomammillary nucleus, a limited region where cell bodies of the histaminergic neurons are located, histamine release was not altered. These observations suggest that modafinil may promote waking via the activation of the histaminergic system, although it does not appear to be a direct pharmacological target of modafinil.


Orexins
Glutamate
The sleep-switch
Modafinil: structure
Modafinil and serotonin
Modafinil and the aviator
Modafinil and the marmoset
Modafinil: pharmacokinetics
Modafinil as an antidepressant
Modafinil versus amphetamine
Modafinil versus methylphenidate
Modafinil v amphetamine v placebo
Histamine, orexins and the narcoleptic dog




Refs
and further reading

Purchase Modafinil

HOME
HedWeb
Nootropics
erythroxylum-coca.com
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Good Drug Guide

The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family