Modafinil and Hangovers | What You MUST Know

Tomas Thorne

Last Updated: February 2, 2023


Who would ever think that Modafinil and hangovers would mix well?

We know for certain that mixing Modafinil and alcohol together isn’t the world’s smartest strategy. Having a stimulant and a depressant simultaneously act against each other is a recipe for disaster.

Not to mention the numerous Modafinil side effects that are made far worse by the presence of too much alcohol.

Little do most people know that a “Modafinil hangover cure” exists. It’s entirely possible to fix a painful hangover with 100-200 mg of Modafinil and some other common-sense tactics.

By combining the effects of this smart drug against a hangover, you can save your productivity from going down the drain. You’ll be able to get the most important things done, just like any other ordinary day.

Instead of feeling like alcohol-induced death, you’ll have superior focus and a renewed supply of energy.

There’s no way you won’t get things done when you have Modafinil by your side.

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Disclaimer: The contents of are for informational and educational purposes only. We do not provide legal advice. Likewise, we do not provide medical advice, diagnosis, or treatment. Please consult your physician prior to consuming Modafinil or related nootropics. Your access to is subject to our full Disclaimer and Terms of Use.

What is Modafinil?

Let’s provide some background information on Modafinil to help you understand why it has the potential for being a hangover cure.

Modafinil is a wakefulness-promoting agent that is classified as a central nervous system (CNS) stimulant despite its mechanism of action being far different from psychostimulants such as amphetamines [1].

It is approved by the FDA to treat excessive daytime sleepiness in three medical conditions:

  • Obstructive sleep apnea
  • Work shift sleep disorder
  • Narcolepsy

Yet Modafinil has emerged over the past 2 decades as one of the world’s most powerful smart drugs. It provides several cognition-enhancing effects such as increased focus and an improved ability to concentrate on one task for longer periods of time.

So much so that it has been studied in healthy non-sleep deprived individuals to determine its effectiveness [2]:

“Modafinil reliably enhanced task enjoyment and performance on several cognitive tests of planning and working memory…The findings confirm that modafinil can enhance aspects of highly demanding cognitive performance in non-sleep deprived individuals.”

But how does this lead to people making a connection between Modafinil and hangovers?

Is there an interaction between Modafinil and alcohol, one where the obvious decreases in cognitive ability that follow a night of heavy drinking are somehow eliminated?


Modafinil and Hangovers | The Basics

Before we get into discussing a “Modafinil hangover cure”, we should explain the science of getting hungover in further detail.

A hangover can be defined as the mental and psychological duress one experiences in the form of unpleasant side effects when a person consumes too much alcohol. “Too much” is entirely subjective, as each person is unique in how much alcohol they can tolerate.

According to the Mayo Clinic, the following outcomes are quite common with excessive alcohol consumption [3]:

  • Irritates your stomach, which could account for post-hangover vomiting and nausea.
  • Drops your blood sugar levels, which may explain the bodily weakness and sudden mood shifts
  • Impairs your quality of sleep, thereby making you far more fatigued when you wake up.
  • Makes you urinate more, thus you become more dehydrated
  • Expands your blood vessels, which can lead to headaches.
  • Triggers an inflammatory response from your immune system, which impairs your cognitive functions even further.

A lot of these effects come from the undue stress placed on the liver to metabolize ~90% of the alcohol you ingest [4]:

“The higher someone’s blood alcohol content, the longer it takes to process alcohol. The liver can only process a certain amount of alcohol at a time (roughly one drink per hour).

When someone has too much to drink, the alcohol left unprocessed by the liver circulates through the bloodstream. The alcohol in the blood starts affecting the heart and brain, which is how people become intoxicated”

The negative effects of hangovers on one’s cognitive ability are the primary reason why frequent drinkers are in search of an effective hangover cure. Therefore, the key is to look for a solution that rapidly returns your brainpower to pre-alcohol levels.

Modafinil has already seen some use as a hangover cure amongst Wall Street professionals. Based purely on anecdotal reports, it appears to enhance alertness, restore concentration, and improve memory in the morning after a rough night of drinking [5].

This can be attributed to Modafiniml’s proven ability to reduce fatigue in individuals suffering from depression, extreme sleep deprivation, and multiple sclerosis [6].

As an interesting side note, some studies suggest that Modafinil may help alcoholics reduce their impulsivity and – by extension – lower alcohol consumption [7].

So how exactly can Modafinil be used as part of a foolproof game plan to cure hangovers?


How to “Cure” Hangovers with Modafinil

The “Modafinil hangover cure” we’re about to present doesn’t solely involve taking a white pill and expecting it to work like magic.

It involves addressing every possible symptom of alcohol-induced hangovers, starting from the very second you wake up. We’ve combined scientific research with the personal experience of hundreds of Modafinil users to formulate this protocol.

Without further ado, here is our detailed plan for combining Modafinil and hangovers in the best way possible…

  • Get Some Extra Sleep

People who get as much sleep as possible tend to experience less severe hangovers. We strongly recommend a minimum of 7 hours for that very reason, seeing as sleep quality is automatically reduced after consuming large amounts of alcohol [8].

We also do not recommend setting an alarm. You should be waking up naturally, regardless of whether you intend to take Modafinil upon waking up or not.

  • Nice Long Shower

The most important thing for curing hangovers is some form of physical movement. Dragging yourself out of bed and into the shower will ensure your day starts off right.

You can choose to take a hot shower, a cold shower, or a contrast shower. Whichever one wakes you up the most. 10-20 minutes of bathing yourself should suffice.

  • Hydrate Yourself


Due to alcohol’s significant effects on dehydration, you will want to increase your fluid intake on the day of the hangover. More fluids will help your body process the remaining alcohol at a much faster pace.

Over the course of the day, we recommend drinking at least one gallon (4 liters) of water. Start your day immediately with 20 ounces (0.5 liters) of water.

As a side note, it would be wise to increase your water intake on the night you are drinking – a minimum of 1 glass of water per glass of alcohol

  • Eat A Large, Hearty Breakfast

In addition to re-hydrating yourself, you should have your first meal of the day as soon as you wake up.

You want this meal to be rather large in size, focusing on the nutrients, vitamins, and electrolytes depleted by drinking alcohol.

This recommendation is entirely subjective with regards to specific foods, but commonly recommended dietary choices include [9]:

  • Eggs
  • Avocado
  • Dark leafy greens, ex. spinach
  • Pickles
  • Meat
  • Oatmeal
  • Sweet potatoes
  • Blueberries
  • Chicken noodle soup

You won’t go wrong by loading up on complex carbohydrates, foods with high protein, and healthy fat sources.

  • Load Up On Electrolytes

Magnesium, potassium, and sodium are just some of the electrolytes depleted by alcohol consumption. This is noteworthy because low levels of electrolytes can lead to symptoms such as fatigue and dizziness [10].

Therefore, you should consume some electrolytes both at the start of the day and throughout the course of the entire day to restore an optimal balance of electrolytes in your body

Our personal recommendations for electrolyte-dense sources are either coconut water, Pedialyte or Gatorade, as all three have been proven to be effective at rehydration. However, coconut water is easier to consume in larger amounts without causing stomach upset [11].

  • Take 200 mg of Modafinil

Now that you are fully awake, well-hydrated, and well-fed, it’s finally time to put the “Modafinil hangover cure” to good use.

200 milligrams is the higher end of what an ideal Modafinil dosage would be, as we are attempting to over-ride the fatigue and exhaustion brought about by the hangover.

  • Immediately Start Being Productive

Right after you take 200 mg of Modafinil, start working on an important task immediately. Some users like to have an espresso at their side while working for an extra boost in productivity.

If you have done everything correctly up until this point, you should be able to achieve 8-12 hours worth of work without feeling tired or requiring a nap.

  • One Last Meal Before Bed

We recommend making your last meal of the day as large as the first meal.

Due to Modafinil’s appetite-suppressing effects, you don’t want to go to bed malnourished. A larger meal will aid with falling asleep [12], ensuring you wake up the next morning feeling refreshed.

Be Careful!

Despite the fact that Modafinil and hangovers can simultaneously co-exist together, there are a few precautions you have to take.

First, please remember that no formal scientific studies have been done on the combination of Modafinil and alcohol together.

While drug interactions are often studied, there’s little information on how the body reacts to Modafinil while breaking down the toxins from a night of binge drinking.

In fact, all we know is that the official product monograph does not recommend taking both drugs at the same time [13]:

“Patients should be advised that the use of PROVIGIL in combination with alcohol has not been studied. Patients should be advised that it is prudent to avoid alcohol while taking PROVIGIL.”

Second, you are putting your health at risk when you combine a powerful CNS stimulant (Modafinil) with a powerful CNS depressant (alcohol).

Everybody responds differently and the results are entirely unpredictable [14, 15]:

“Mixing stimulants and depressants puts the body under immense pressure. The cardiovascular, respiratory and central nervous systems are put into a frenzy with the simultaneous mixed messages to speed up and slow down.”

“The combined effects is a minimization of the symptoms of either substance, thus creating the illusion that the person is not as intoxicated as they actually are…Uppers can conceal warning signs that profound CNS depression is occurring while downers might mask a dangerously accelerated heartbeat.”

Third, some of the most common Modafinil side effects are dehydration and nausea [16], which are also caused by a hangover.

Even though you are taking in a larger quantity of water than normal, Modafinil may add on to the dehydration you are experiencing from your hangover.

In short: The “Modafinil hangover cure” is something that should be used once in a while, and NOT as a mask to cover up problems with frequent drinking and/or alcohol abuse.

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User Experiences

What do other smart drug users on the Internet have to say about Modafinil and hangovers?

Unfortunately, there are very few anecdotal reports regarding the use of Modafinil as a hangover cure. At best, its effectiveness seems to be mixed.

Some individuals swear by the use of Modafinil as a way to offset the negative effects of a hangover [17, 18]:

“I take modafinil a few times a week as I see necessary for school work. I noticed that when I take it after a night of heavy drinking the next day hangover is greatly reduced. I could wake up with a pounding headache and an overall hate of life but once I pop a modafinil, half hour later I’m alert and usually in a good mood.”

“It allows me to be incredibly productive a day after moderate drinking. Without it, it would be a wasted day.”

Other users claim the opposite effect, stating that Modafinil made their hangovers so much worse — which is cause for alarm [19, 20]:

“After dosing 100mg Modalert my hangover seemed to only get worse. I wouldn’t say anything that one couldn’t deal with but definitely not a hangover you want to be at work for. mouth feels dryer than usual, stomach feeling a little queezy…This may just be a one off in my case but I definitely don’t recommend taking moda if you are hungover”

“So I went through my day with my hangover, and the modafinil (100 mg) did it’s job and kept me alert. Thing were going quite well bit the headache kicked in [3 hours later], and it was bareable. After getting home, it got a lot worse and I haven’t been able to do much since.”

In both cases, the users recommended using no more than 50mg of Modafinil if it is being taken to fix a hangover.

At the end of the day, you will have to attempt the “Modafinil hangover cure” we suggested and see if it works for you. It may work for some individuals while producing a negligible difference for others.

Modafinil and Hangovers | Verdict

Is mixing Modafinil and hangovers a good idea?

There is a small amount of evidence that suggests a Modafinil hangover fix is possible and may indeed be effective. However, it is imperative to combine Modafinil with other sound practices for best results — sleep, hydration, nutrition, etc.

At the very least, you can reduce the productivity-killing effects of excessive alcohol consumption and avoid falling behind your important tasks by a full day.

Please do not attempt to do this on a regular basis — heavy drinking and hangovers are bad for your health!

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  1. Modafinil. Retrieved August 21, 2020.
  2. Müller U, Rowe JB, Rittman T, Lewis C, Robbins TW, Sahakian BJ. Effects of modafinil on non-verbal cognition, task enjoyment and creative thinking in healthy volunteers. Neuropharmacology. 2013;64(5):490-495. doi:10.1016/j.neuropharm.2012.07.009
  3. Do Alcoholics Get Hangovers? Retrieved August 23, 2020.
  4. Alcohol and the Liver. Retrieved August 23, 2020.
  5. Wall Street’s Favorite Drugs. Retrieved August 17, 2020.
  6. Marin H, Menza MA. Specific treatment of residual fatigue in depressed patients. Psychiatry (Edgmont). 2004;1(2):12-18.
  7. Modafinil may help some people to reduce drinking by improving their impulse control. Retrieved August 22, 2020.
  8. Devenney LE, Coyle KB, Roth T, Verster JC. Sleep after Heavy Alcohol Consumption and Physical Activity Levels during Alcohol Hangover. J Clin Med. 2019;8(5):752. Published 2019 May 27. doi:10.3390/jcm8050752
  9. The 23 Best Hangover Foods. Retrieved August 21, 2020.
  10. Electrolyte Imbalance. Retrieved August 22, 2020.
  11. Saat M, Singh R, Sirisinghe RG, Nawawi M. Rehydration after exercise with fresh young coconut water, carbohydrate-electrolyte beverage and plain water. J Physiol Anthropol Appl Human Sci. 2002;21(2):93-104. doi:10.2114/jpa.21.93
  12. Gallagher T, You YJ. Falling asleep after a big meal: Neuronal regulation of satiety. Worm. 2014;3:e27938. Published 2014 Jan 31. doi:10.4161/worm.27938
  13. PROVIGIL® (modafinil) Tablets [C-IV]. Retrieved August 20, 2020.
  15. Dangers of Mixing Uppers and Downers. Retrieved August 24, 2020.
  16. Modafinil. Retrieved August 20, 2020.
  17. Modafinil is my go to hangover cure. Retrieved August 22, 2020. r/Drugs
  18. Does it help with hangovers? Retrieved August 22, 2020. r/modafinil
  19. Modafinil When You’re Hungover, Don’t do it. Retrieved August 22, 2020. r/afinil
  20. Headache – Modafinil or hangover? Retrieved August 22, 2020. r/afinil

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