Modafinil Vs. Ritalin | Benefits, Side Effects, and Comparison

Modafinil Vs Ritalin

Many nootropics researchers are interested in the cognition-enhancing effects of modafinil vs. Ritalin.

These two drugs are similar in many ways, but there are also some striking differences between the two that nootropics researchers and subjects should be aware of.

Here’s how modafinil and Ritalin compare.

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What Is Modafinil?

Modafinil is a prescription eugeroic, or a wakefulness agent. It’s approved for use in people with sleep disorders like sleep apnea, shift work sleep disorder, and narcolepsy. It helps people with these conditions stay awake during the day or during their shift at work. [1]

However, it’s also prescribed for many other conditions, including depression and attention deficit hyperactivity disorder (ADHD). [2, 3]

Additionally, it offers a number of nootropic, or cognition-enhancing benefits — which has made modafinil a subject of interest with nootropics researchers who are interested in maximizing or optimizing cognitive performance. [4]

Modafinil is available under the brand name Provigil, and it’s manufactured by Cephalon Labs.

modafinil

What Is Ritalin?

Ritalin is the brand name of the drug methylphenidate. It is a prescription medication approved for use in ADHD. It’s a stimulant medication, which paradoxically provides a calming and grounding effect to people with ADHD that allows them to focus more. It can also be prescribed to people with sleep disorders like sleep apnea or narcolepsy. As a stimulant, it helps these people stay awake. [5]

Like modafinil, it is also of great interest to nootropics researchers. It’s also widely used as a study aid to help college students stay up all night and focus, although this use is illegal. [6]

Both modafinil and Ritalin require a prescription to be legally obtained.

Mechanisms of Action

Although the mechanism of action of modafinil isn’t fully understood, researchers believe that it limits the reuptake of dopamine into nerve cells, allowing for higher levels of dopamine to circulate in the brain. [7]

Ritalin works in a similar manner, by increasing circulating levels of both norepinephrine and dopamine — which both stimulates (making you feel more alert) and speeds up your brain activity. [8]

Modafinil vs. Ritalin | Comparison

Here are the ways that modafinil and Ritalin are comparable:

  • Uses. Both modafinil and Ritalin are primarily used for ADHD and sleep disorders thanks to their stimulant effects. Modafinil is approved for sleep disorders, but commonly prescribed “off label” for ADHD. Conversely, Ritalin is approved for both ADHD and sleep disorders by the U.S. Food and Drug Administration.
  • Effects. Both modafinil and Ritalin offer stimulant effects, helping to promote alertness. They also have some nootropic effects, like improving concentration and focus. [9]
  • Mechanisms of action. Both modafinil and Ritalin inhibit the reuptake of dopamine into the nerves, allowing for higher levels of this stimulating neurotransmitter to circulate in the brain. Ritalin also involves the stimulant neurotransmitter norepinephrine.
  • Legal status. Modafinil and Ritalin both require a prescription in the United States.

Direct Comparison Studies

Several studies have compared the effects of modafinil and Ritalin, primarily because they are both used to treat the same conditions. Most of the head-to-head studies have been done with participants who have ADHD.

One large meta-analysis (review of several studies) comparing modafinil, Ritalin, and other well-known ADHD medications found that all were more effective for treatment than placebo. Teachers with students taking these ADHD medications rated modafinil and Ritalin as noticeably more effective. Adults taking the medications rated Ritalin higher than modafinil for effectiveness. [10]

Another study found that high-dose modafinil (600 mg per day) in healthy people may cause alterations in emotion processing that aren’t caused by a 60 mg dose of Ritalin. [11]

In a head-to-head study comparing the effectiveness of modafinil and Ritalin as nootropic agents for chess players (when compared to a placebo), researchers noted that both modafinil and Ritalin improved chess performance and lead to higher scores in the game. [12]

modafinil

Side Effects

Here are the potential side effects of both modafinil and Ritalin, directly from the U.S. National Library of Medicine website: [1, 5]

Modafinil 

“headache
dizziness
difficulty falling asleep or staying asleep
drowsiness
nausea
diarrhea
constipation
gas
heartburn
loss of appetite
unusual tastes
dry mouth
excessive thirst
nosebleed
flushing
sweating
tight muscles or difficulty moving
back pain
confusion
uncontrollable shaking of a part of your body
burning, tingling, or numbness of the skin
difficulty seeing or eye pain”

Ritalin

“nervousness
irritability
difficulty falling asleep or staying asleep
dizziness
nausea
vomiting
loss of appetite
weight loss
stomach pain
diarrhea
heartburn
dry mouth
headache
muscle tightness
drowsiness
uncontrollable movement of a part of the body
restlessness
decreased sexual desire
heavy sweating
back pain”

Additionally, the U.S. National Library of Medicine also details severe side effects and complications that require immediate medical care:

Modafinil

“rash
blisters
peeling skin
mouth sores
hives
itching
hoarseness
difficulty breathing or swallowing
swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
chest pain
fast, pounding, or irregular heartbeat
frenzied, abnormally excited mood
hallucinating (seeing things or hearing voices that do not exist)
anxiety
depression
thinking about killing or harming yourself”

Ritalin

“fast, pounding, or irregular heartbeat
chest pain
shortness of breath
excessive tiredness
slow or difficult speech
fainting
weakness or numbness of an arm or leg
seizures”

Finally, it’s important that the prescribing physician is aware of any other medications the patient is taking, or any other medical conditions they have.

Our Experience

Many nootropics researchers have done extensive testing on the cognitive effects of both modafinil and Ritalin.

In general, modafinil is preferred for its nootropic benefits.

Ritalin is habit-forming and can induce feelings of euphoria, and many people who have tried it for off-label uses describe quickly wanting to take higher and higher doses, and wanting to take doses even when they didn’t need the extra focus. Many people also say that Ritalin makes them feel like a “zombie” and detached, although it is effective at increasing focus and keeping subjects awake for long periods of time.

On the other hand, modafinil produces milder effects with no euphoria, no documented risk of addiction, no withdrawal symptoms, and no “crash” after taking it.

For anyone except for the narrow subset of people who qualify for a prescription for Ritalin, modafinil appears to be a much better nootropic.

Common Uses

Here are some of the most common uses of both Ritalin and modafinil:

  • ADHD. Stimulants like Ritalin and modafinil are used for ADHD because they increase dopamine levels, which helps boost attentiveness and focus. Although this seems paradoxical, stimulants appear to have almost a calming effect on people with ADHD, allowing them to focus better on one task at a time. [8]
  • Sleep disorders. Stimulants have a more straightforward effect on people with sleep disorders. They help them to stay awake when they need to be awake, which is during their shift for people with shift work sleep disorder, and during the day for people with other sleep disorders like sleep apnea and narcolepsy.
  • Nootropic enhancement. In addition to their stimulant effects, both modafinil and Ritalin have some nootropic effects as well. Nootropics researchers report increased focus and concentration, better task performance and test taking, and more alertness. These cognition-enhancing benefits have been noted in peer-reviewed research studies, as well.
modafinil-44

Main Differences

Some of the key differences between modafinil and Ritalin include:

  • Potential to be habit forming. Regarding Ritalin, the U.S. National Library of Medicine warns, “Methylphenidate can be habit-forming. Do not take a larger dose, take it more often, take it for a longer time, or take it in a different way than prescribed by your doctor. If you take too much methylphenidate, you may find that the medication no longer controls your symptoms, you may feel a need to take large amounts of the medication, and you may experience unusual changes in your behavior.” Anecdotal reports from nootropics researchers align with this — as some report that they found themselves taking larger and larger doses, or wanting to take Ritalin when they didn’t need to. On the other hand, modafinil does not appear to be habit forming or to have addictive properties. [5]
  • Neurotransmitter involvement. Both modafinil and Ritalin affect dopamine signaling to increase circulating levels of dopamine in the brain, but Ritalin also involves norepinephrine — another neurotransmitter that provides stimulating effects.
  • Effects. Ritalin is known to have more powerful, profound effects than modafinil. While many nootropics researchers consider modafinil a moderately effective nootropic, they consider Ritalin a “hard drug” — especially in light of its addictive properties.
  • Side effects. Many of the milder side effects of Ritalin and modafinil are similar, but Ritalin generally has more side effects of a greater intensity than modafinil. For instance, many researchers report that Ritalin makes them feel detached and almost “robotic” and completely neutralizes their appetite. Ritalin is also habit forming, whereas this doesn’t appear to be the case for modafinil.

What’s Best for You?

It’s important to discuss your concerns about either of these medications with your prescribing physician.

We prefer modafinil because it doesn’t appear to be habit-forming like methylphenidate, and it also offers similar cognitive benefits in addition to being used as a treatment for both sleep disorders and ADHD. Compared to Ritalin, modafinil also doesn’t seem to cause extreme mood changes or cause withdrawals when you discontinue use.

Again, though, it’s important to discuss these medications with your healthcare provider.

Modafinil vs. Ritalin | Verdict

Modafinil and Ritalin are similar, but extremely unique medications. Modafinil is a wakefulness agent that is approved for use in people with sleep disorders, but is also used off label for ADHD and as a nootropic. Likewise, Ritalin is approved for ADHD and sleep disorders, and is a substance of interest among nootropics researchers.

Generally, nootropics researchers and experts endorse modafinil over Ritalin because Ritalin is habit forming, may cause unpleasant side effects, and can be too powerful for many people.

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References

  1. U.S. National Library of Medicine. Modafinil. MedlinePlus website. February 15, 2016. https://medlineplus.gov/druginfo/meds/a602016.html
  2. Malhi GS, Byrow Y, Bassett D, et al. Stimulants for depression: On the up and up?. Aust N Z J Psychiatry. 2016;50(3):203-207. doi:10.1177/0004867416634208
  3. Wang SM, Han C, Lee SJ, et al. Modafinil for the treatment of attention-deficit/hyperactivity disorder: A meta-analysis. J Psychiatr Res. 2017;84:292-300. doi:10.1016/j.jpsychires.2016.09.034
  4. Battleday RM, Brem AK. Modafinil for cognitive neuroenhancement in healthy non-sleep-deprived subjects: A systematic review. Eur Neuropsychopharmacol. 2015;25(11):1865-1881. doi:10.1016/j.euroneuro.2015.07.028
  5. U.S. National Library of Medicine. Methylphenidate. MedlinePlus website. July 15, 2019. https://medlineplus.gov/druginfo/meds/a682188.html
  6. Wilms W, Woźniak-Karczewska M, Corvini PF, Chrzanowski Ł. Nootropic drugs:Methylphenidate, modafinil and piracetam – Population use trends, occurrence in the environment, ecotoxicity and removal methods – A review. Chemosphere. 2019;233:771-785. doi:10.1016/j.chemosphere.2019.06.016
  7. Hashemian SM, Farhadi T. A review on modafinil: the characteristics, function, and use in critical care. J Drug Assess. 2020;9(1):82-86. Published 2020 Apr 4. doi:10.1080/21556660.2020.1745209
  8. Sharma A, Couture J. A review of the pathophysiology, etiology, and treatment of attention-deficit hyperactivity disorder (ADHD). Ann Pharmacother. 2014;48(2):209-225. doi:10.1177/1060028013510699
  9. Iglseder B. Doping für das Gehirn [Doping for the brain]. Z Gerontol Geriatr. 2018;51(2):143-148. doi:10.1007/s00391-017-1351-y
  10. Cortese S, Adamo N, Del Giovane C, et al. Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis. Lancet Psychiatry. 2018;5(9):727-738. doi:10.1016/S2215-0366(18)30269-4
  11. Schmidt A, Müller F, Dolder PC, et al. Acute Effects of Methylphenidate, Modafinil, and MDMA on Negative Emotion Processing. Int J Neuropsychopharmacol. 2018;21(4):345-354. doi:10.1093/ijnp/pyx112
  12. Franke AG, Gränsmark P, Agricola A, et al. Methylphenidate, modafinil, and caffeine for cognitive enhancement in chess: A double-blind, randomised controlled trial. Eur Neuropsychopharmacol. 2017;27(3):248-260. doi:10.1016/j.euroneuro.2017.01.006

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