Modafresh Review [2022 • Guide] Uses, Side Effects & Dosing

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Curious about Modafresh? This Modafresh Review will outline the uses, side effects and dosing of Modafresh for anyone wanting to learn more about this well-known nootropic agent.

Modafresh is a generic brand of modafinil that’s a cost-effective alternative to brand-name modafinil products like Provigil. Modafinil and its related compounds are a mainstay in the nootropics world, and are all the talk of biohackers and cognitive enhancement experts.

So what benefits does Modafresh offer? What side effects does it produce? Is it legal? And how does it compare to other modafinil brands like Modalert, Modvigil and Provigil?

Below we’ll aim to answer those questions and more.

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Disclaimer: The contents of Modafinil.com are for informational and educational purposes only. We do not provide legal advice. Likewise, we do not provide medical advice, diagnosis, or treatment. Please consult your physician prior to consuming Modafinil or related nootropics. Your access to Modafinil.com is subject to our full Disclaimer and Terms of Use.

What Is Modafresh?

Modafresh is a generic version of modafinil that’s manufactured by Sunrise Pharma [1]. It comes in round pills that each contain 200 mg of modafinil. As a generic medication, Modafresh is virtually identical to brand-name modafinil such as Provigil of Cephalon Inc.

Modafresh Benefits

The benefits of Modafresh as a modafinil generic can be categorized as follows:

  • Price
  • Research-Backed Medical Benefits
  • Cognitive Enhancement

Let’s look at each in more detail.

Price

The main benefit of Modafresh is that, as a modafinil generic, it’s a cost-effective alternative to pricey brand-name drugs like Provigil. Patients who receive a modafinil prescription from their doctor may be attracted to Modafresh due to its affordable prices.

Research-Backed Medical Benefits

Modafresh offers the exact same research-backed medical benefits as all other modafinil products, including brand-name and generic modafinil. The main benefit of modafinil is that it acts as a eugeroic, or “wakefulness-promoting agent.”

Modafinil is prescribed by doctors to treat patients who suffer from sleep-wake disorders that cause excessive daytime sleepiness like:

  • Narcolepsy,
  • Obstructive sleep apnea, and
  • Shift work sleep disorder.

As a eugeroic, modafinil helps counteract excessive sleepiness and lets patients stay awake throughout the day. In some cases, doctors may prescribe modafinil to treat other conditions that cause daytime drowsiness or fatigue, such as Seasonal Affective Disorder (SAD).

While modafinil’s exact mechanism of action isn’t fully understood, research by Pigeau R et al found that modafinil has a positive effect on “mood, fatigue and cognitive performance” during periods of “sustained mental work” [2]. Later research by Chapotot F et al found that modafinil has a “distinctive effect” on “homeostatic and circadian modulation” [3]. In 1997, Baranski JV et al found that modafinil had a strong effect on cognitive performance in sleep-deprived research subjects [4].

Research has also indicated that modafinil may be beneficial for treating cognitive and psychological disorders. For example, a randomized, double-blind and placebo-controlled study by Biederman J et al found that once-daily and divided doses of modafinil could potentially help treat children who suffer from attention deficit hyperactivity disorder (ADHD) [5]. However, this is not an FDA-approved use of modafinil and the FDA's Pediatric Advisory Committee has warned against the use of modafinil in children due to “serious dermatologic adverse effects and psychiatric events” [6].

Modafinil has also been used to treat cases where patients are dependent on, or addicted to, other substances. For instance, a double-blind, placebo-controlled trial of modafinil by Dackis CA et al found that modafinil can help treat cocaine dependence [7]. More recent research by Mereu M et al has suggested that modafinil can be used as a treatment for substance use disorders [8].

Modafinil as a Cognitive Enhancement Agent

While modafinil is not approved for use anywhere in the world as a cognitive enhancer, widespread anecdotal evidence suggests that it is widely taken for this purpose as a “nootropic” or so-called “smart drug” [9]. A study by Battleday RM et al found that modafinil “directly increases cortical catecholamine levels, indirectly upregulates cerebral serotonin, glutamate, orexin, and histamine levels” [10]. The authors concluded that modafinil offers the potential for “cognitive neuroenhancement in healthy non-sleep-deprived subjects.”

These findings are supported by separate research by Minzenberg MJ et al which found that modafinil has a strong effect on cognition [11]. Individuals who are interested in the potential cognitive benefits offered by modafinil may be attracted to Modafresh by its ease of availability and lower price point compared with brand-name modafinil products like Provigil.

Now that we’ve looked at Modafresh’s main benefits, covering both approved and off-label uses, let's look at some of its side effects.

Modafresh Side Effects

There is no peer-reviewed scientific evidence into the side effects of Modafresh specifically. However, as a generic version of modafinil, Modafresh contains the same active ingredient and therefore has the same side effect profile.

Modafinil is an FDA-approved eugeroic that is sold worldwide under various brand names such as Vigil, Alertec and Provigil. It has been widely studied and its side effect profile is well known and well understood [6].

The most common modafinil side effects are:

  • Headaches and/or feeling of dizziness,
  • Increased anxiety and/or nervousness,
  • Upset stomach and/or nausea,
  • Difficulties sleeping (including insomnia),
  • Stuffy nose, and
  • Back pain.

Modafinil’s full range of side effects is vast and includes skin reactions, allergic reactions, fever, shortness of breath, and swelling in the face, eyes, lips, tongue or throat. Patients who experience any side effects when taking any type of modafinil including Modafresh are advised to cease use immediately and call their doctor for medical advice.

To date, there have been no studies into the side effects caused by modafinil when taken as a cognitive enhancer by healthy individuals. However, one study looked at what happened when patients who had been incorrectly diagnosed with narcolepsy were given modafinil [12].

The study noted that the research subjects experienced a range of side effects, the most frequent of which were “headaches, nausea, anxiety, insomnia, lumbago, diarrhea, dyspepsia, rhinitis and vertigo.”

As modafinil inhibits the reuptake of dopamine in the brain [13], there have been concerns that the drug may lead to dependence and may be habit-forming. This is one of the main reasons why modafinil is a prescription medicine throughout Europe and in most countries worldwide.

However, most studies have found that modafinil has a low risk of addiction and dependence. One study into a case of modafinil dependence involved a case where the patient was taking 1,200 mg of modafinil per day [14]. This is far more than the standard clinical dose, which we’ll discuss later.

Where To Buy Modafresh Online? | 2022 Guide

Modafresh is widely available online but the onus is on the buyer to ensure that they abide by all local laws when making a purchase. While there are some countries where modafinil is either unregistered or its sale is unrestricted, in most countries modafinil is a prescription-only medicine that can only be sold to patients with a valid prescription.

Patients interested in buying modafinil online may be interested in Modafresh because it costs far less than brand-name modafinil like Provigil. For those curious about where to buy Modafresh, one of the most established vendors that our team has reviewed in Modafinil XL.

Modafinil XL is a reputable online vendor that sells high-quality Modafresh to patients around the world. It has numerous positive reviews on sites such as Trustpilot.

When our team reviewed their service, we found that they offered many benefits including:

  • A Highly-Detailed Website: Modafinil XL's website contains numerous articles, guides and reviews of modafinil products including Modafresh. Their information is impartial and unbiased and we believe it is helpful to anyone looking to make an informed decision about whether to buy Modafresh.
  • Reasonable Pricing: Modafinil XL offers Modafresh at competitive prices starting at just $29 for 10 Modafresh 200mg pills. The price-per-pill drops significantly for larger orders of 200, 300, or 500 pills. At these volumes, other discounts such as free shipping, take effect and make the price of each pill more competitive.
  • Fast Shipping: Orders from Modafinil XL typically arrive within 7-12 business days, depending on a range of factors including where the customer is ordering from and the type of delivery they select. Standard shipping takes 14-30 days and usually costs $39 but is complimentary on orders over $130. Express shipping takes 10-18 business days and usually costs $49 but is complimentary on orders over $180. There are several other shipping options available for additional costs.
  • Great Deals: As a bonus, Modafinil XL includes 20 free pills (10 modafinil pills and 10 armodafinil pills) with every order. You’ll also receive a $25 coupon for your second order.
  • 20% Bitcoin Discount: If you choose to pay for your order with Bitcoin or another cryptocurrency, Modafinil XL will give you a 20% discount. Please be aware that this option may incur additional charges depending on the customers’ local and payment method.
  • Guaranteed Delivery: Patients who order Modafresh from Modafinil XL can do so practically risk-free. Delivery is guaranteed and Modafinil XL offers free reshipments and full refunds in the event of lost or missing orders.

Overall, our team had a positive experience when ordering Modafresh from Modafinil XL. Patients who are interested in buying competitively-priced Modafresh would certainly stand to gain much from this vendor.

Order Modafinil online from one of the best vendors in the world!
Solid prices, quick shipping, and guaranteed delivery.

Is Modafresh Legal?

As generic modafinil, Modafresh is subject to all the same legal restrictions as modafinil. Modafinil is a prescription-only medication throughout Europe and in most Western countries including the USA [15], U.K. and Australia. This means that patients who want to buy this drug need to have a valid prescription from a doctor.

Most doctors will only prescribe modafinil for sleep-wake disorders that cause excessive daytime sleepiness like narcolepsy, sleep apnea and shift work sleep disorder. Most physicians will ask patients to take an overnight sleep study, to make an accurate diagnosis. As discussed above, modafinil is sometimes prescribed to treat cognitive disorders.

In certain countries, modafinil is unregistered or its sale is unrestricted. Patients in these countries can buy modafinil online, or in some cases over-the-counter, without a prescription.

How Long Does Modafresh Take To Work?

Modafresh works exactly like Provigil and any other type of brand-name or generic modafinil. Patients with SWSD are typically advised to take modafinil around one hour before their shift begins [6]. Anecdotally, this suggests that Modafresh takes up to 60 minutes to work. However, everyone responds differently to medicines and the exact time will vary from one person to the next.

Modafresh Dosage and Tolerance

Modafresh can be used in the same dosage as Provigil and any other form of modafinil. The usual adult dose for narcolepsy and obstructive sleep apnea is one 200 mg pill daily. The pill can be taken in the morning, with or without food.

Adults suffering from SWSD are typically advised by their doctor to take one 200 mg pill around one hour before the start of their work shift.

In the EU, doctors can increase a patient’s dose to 400 mg/day if the response to a lower dose is insufficient.

Modafresh vs. Modalert vs. Modvigil vs. Provigil

Patients who have received a modafinil prescription may learn that there are several different brands of generic modafinil to choose from including Modafresh, Modalert and Modvigil. This begs the question: What’s the difference between these brands? And how do they compare with brand-name modafinil like Provigil?

On a chemical level, all four of these drugs are virtually identical. Modafresh, Modalert and Modvigil are all generic versions of modafinil and contain exactly the same active ingredient as brand-name modafinil like Provigil. All four drugs come in tablet form and contain the same dose – 200 mg.

The only difference in the chemical composition of these drugs is the types and amounts of fillers used in the manufacturing process. In practical terms, this does not affect the benefits offered by these drugs. Many people believe that generic drugs are inferior or “knock-off” products, but this simply isn’t true. Generic drugs are designed to work identically to their brand-name counterparts.

The main quantifiable difference between these four drugs is the price. All three generic brands – Modafresh, Modalert, and Modvigil – cost much less than brand-name modafinil products like Provigil.

The online vendor that we reviewed above – Modafinil XL – charges $29 for ten tablets of generic modafinil, no matter whether you order Modafresh, Modalert or Modvigil.

However, when you place a larger order, you will notice a difference; 200 Modalert pills cost $249, and 200 Modafresh pills cost $219, while 200 Modvigil pills cost just $199.

When our team tested these drugs, we noticed a few slight differences between them. There’s no empirical scientific evidence to support our observations and others may disagree, but this is what we found during our testing.

We found that Modalert lasts slightly longer than Modvigil and Modafresh overall. In our team’s opinion, Modalert is the most potent and powerful form of generic modafinil on the market, followed by Modvigil and then Modafresh.

That's how we think Modafresh stacks up against its generic counterparts Modalert and Modvigil.

Modafresh Review | Verdict?

For those interested in reading a full review of Modafresh, we hope that our Modafresh Review has left no question unanswered.

Essentially, Modafresh is a generic version of modafinil that works exactly like brand-name versions. Its benefits, side effects and dosage guidelines are all identical to Provigil or any other brand-name modafinil.

The main benefits of Modafresh are that it is widely available online and comes at a much more attractive price point.

Order Modafinil online from one of the best vendors in the world!
Solid prices, quick shipping, and guaranteed delivery.

References

  1. Home – Sunrise Pharmaceutical, Inc.. Sunrise Pharmaceutical, Inc. (2021). Retrieved 5 March 2021, from https://sunrisepharma.com/.
  2. Pigeau R, Naitoh P, Buguet A, McCann C, Baranski J, Taylor M, Thompson M, MacK I I. Modafinil, d-amphetamine and placebo during 64 hours of sustained mental work. I. Effects on mood, fatigue, cognitive performance and body temperature. J Sleep Res. 1995 Dec;4(4):212-228. doi: 10.1111/j.1365-2869.1995.tb00172.x. PMID: 10607161.
  3. Chapotot F, Pigeau R, Canini F, Bourdon L, Buguet A. Distinctive effects of modafinil and d-amphetamine on the homeostatic and circadian modulation of the human waking EEG. Psychopharmacology (Berl). 2003 Mar;166(2):127-38. doi: 10.1007/s00213-002-1315-8. Epub 2003 Jan 28. PMID: 12552359.
  4. Baranski JV, Pigeau RA. Self-monitoring cognitive performance during sleep deprivation: effects of modafinil, d-amphetamine and placebo. J Sleep Res. 1997 Jun;6(2):84-91. doi: 10.1111/j.1365-2869.1997.00032.x. PMID: 9377538.
  5. Biederman J, Swanson JM, Wigal SB, Boellner SW, Earl CQ, Lopez FA; Modafinil ADHD Study Group. A comparison of once-daily and divided doses of modafinil in children with attention-deficit/hyperactivity disorder: a randomized, double-blind, and placebo-controlled study. J Clin Psychiatry. 2006 May;67(5):727-35. doi: 10.4088/jcp.v67n0506. PMID: 16841622.
  6. Provigil: Uses, Dosage, Side Effects, Warnings – Drugs.com. Drugs.com. (2021). Retrieved 5 March 2021, from https://www.drugs.com/provigil.html.
  7. Dackis CA, Kampman KM, Lynch KG, Pettinati HM, O'Brien CP. A double-blind, placebo-controlled trial of modafinil for cocaine dependence. Neuropsychopharmacology. 2005 Jan;30(1):205-11. doi: 10.1038/sj.npp.1300600. PMID: 15525998.
  8. Mereu M, Bonci A, Newman AH, Tanda G. The neurobiology of modafinil as an enhancer of cognitive performance and a potential treatment for substance use disorders. Psychopharmacology (Berl). 2013 Oct;229(3):415-34. doi: 10.1007/s00213-013-3232-4. Epub 2013 Aug 10. PMID: 23934211; PMCID: PMC3800148.
  9. Teodorini, Rachel D et al. “The off-prescription use of modafinil: An online survey of perceived risks and benefits.” PloS one vol. 15,2 e0227818. 5 Feb. 2020, doi:10.1371/journal.pone.0227818
  10. Battleday RM, Brem AK. Modafinil for cognitive neuroenhancement in healthy non-sleep-deprived subjects: A systematic review. Eur Neuropsychopharmacol. 2015 Nov;25(11):1865-81. doi: 10.1016/j.euroneuro.2015.07.028. Epub 2015 Aug 20. PMID: 26381811.
  11. Minzenberg MJ, Carter CS. Modafinil: a review of neurochemical actions and effects on cognition. Neuropsychopharmacology. 2008 Jun;33(7):1477-502. doi: 10.1038/sj.npp.1301534. Epub 2007 Aug 22. PMID: 17712350.
  12. Lopes E, Pereira D, da Silva Behrens NS, de Almeida Fonseca H, Calvancanti PO, de Araújo Lima TF, Pradella-Hallinan M, Castro J, Tufik S, Coelho FM. Cataplexy as a side effect of modafinil in a patient without narcolepsy. Sleep Sci. 2014 Mar;7(1):47-9. doi: 10.1016/j.slsci.2014.07.015. Epub 2014 Aug 19. PMID: 26483900; PMCID: PMC4521649.
  13. Volkow, Nora D et al. “Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications.” JAMA vol. 301,11 (2009): 1148-54. doi:10.1001/jama.2009.351
  14. Krishnan, Raman, and Krishnan Vengadaragava Chary. “A rare case modafinil dependence.” Journal of pharmacology & pharmacotherapeutics vol. 6,1 (2015): 49-50. doi:10.4103/0976-500X.149149
  15. Drug Scheduling. (n.d.). Retrieved from https://www.dea.gov/drug-scheduling

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