Idiopathic Hypersomnia
by
Billiard M, Dauvilliers Y.
Department of Neurology B,
Gui de Chauliac Hospital, Montpellier, France
Sleep Med Rev 2001 Oct;5(5):349-358


ABSTRACT

In contrast to narcolepsy and the Kleine-Levin syndrome, idiopathic hypersomnia is a recently described sleep disorder. Absence of associated clinical features such as cataplexy or megaphagia and characteristic polysomnographic features such as sleep-onset REM episodes render positive diagnosis more uncertain in idiopathic hypersomnia than in the fwo former conditions. Consequently there has been an unfortunate tendency to label all difficult to classify cases of excessive daytime sleepiness as idiopathic hypersomnia. At present due to the description of new disorders such as upper airway resistance syndrome, narcolepsy without cataplexy, delayed sleep phase syndrome, all of which were formerly confused with idiopathic hypersomnia and the clear identification of a "polysymptomatic" or "classic" form of idiopathic hypersomnia, the limits of the disorder become more precise. Still there are a number of cases of isolated excessive daytime sleepiness with no prolonged night sleep, no difficulty waking up, which lay between narcolepsy and genuine idiopathic hypersomnia. Thus there is a definite need to further develop laboratory investigations to help identify and classify these cases. Moreover pathophysiology and pathogenesis are still in their infancy and efforts have to be pursued in this direction. Treatment has not made consistent progress except for the use of a new wake promoting compound, modafinil, which has not yet been evaluated in controlled studies.


Dosage
Dopamine
Glutamate
The sleep-switch
Modafinil: structure
Modafinil and serotonin
Modafinil: pharmacokinetics
Modafinil and the marmoset
Modafinil versus amphetamine
Modafinil for sleepy Parkinsonians
Modafinil versus methylphenidate
Modafinil v amphetamine v placebo




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