Basic
Sleep: A Functional Enigma
ABSTRACT Although continued total sleep deprivation is fatal, the function of sleep remains a mystery. Shorter durations of sleep deprivation are followed by rebound increases
July 3, 2020
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Basic
Basic
It’s Wake-Up Time
Kiss your pillow good-bye. A new breed of drugs promises to do for drowsiness what Prozac did for depression. By Richard Martin In January 2003,
July 3, 2020
July 3, 2020
Basic
A Double-Blind, Placebo-Controlled, Ascending-Dose Evaluation of the Pharmacokinetics and Tolerability of Modafinil Tablets in Healthy Male Volunteers
ABSTRACT A randomized, double-blind, placebo-controlled, ascending-dose study was conducted to evaluate the pharmacokinetic and safety profiles of increasing modafinil doses (200 mg, 400 mg, 600
July 3, 2020
Basic
Narcolepsy. Signs, Symptoms, Differential Diagnosis, and Management
ABSTRACT Narcolepsy is a chronic neurologic disorder characterized by excessive daytime sleepiness and cataplexy and less often by hypnagogic hallucinations and sleep paralysis. While patients
July 3, 2020
Basic
Modafinil-Associated Weight Loss in a Clozapine-Treated Schizoaffective Disorder Patient
ABSTRACT BACKGROUND: We report a case of weight loss associated with modafinil-initiation in a clozapine-treated man with schizoaffective disorder. METHODS: To report the impact of
July 3, 2020
Basic
Wake-Promoting Agents with Different Mechanisms of Action: Comparison of Effects of Modafinil and Amphetamine on Food Intake and Cardiovascular Activity
ABSTRACT Despite efforts to achieve a desirable weight, two-thirds of the population has an elevated body weight. Medications are useful in supporting weight loss, but
July 3, 2020
Basic
Etiologies and Sequelae of Excessive Daytime Sleepiness
ABSTRACT Excessive daytime sleepiness (EDS), the primary complaint of patients seen in sleep clinics, affects up to 12% of the general population. The effects of
July 3, 2020
Basic
Modafinil Enhances the Increase of Extracellular Serotonin Levels Induced by the Antidepressant Drugs Fluoxetine and Imipramine: A dual Probe Microdialysis Study in Awake Rat
ABSTRACT In view of a postulated role of the vigilance-promoting drug modafinil in depression, the interaction of modafinil and two classical antidepressant drugs, fluoxetine and
July 3, 2020
Basic
Adjunctive Modafinil at Initiation of Treatment with a Selective Serotonin Reuptake Inhibitor Enhances the Degree and Onset of Therapeutic Effects in Patients with Major Depressive Disorder and Fatigue
ABSTRACT BACKGROUND: Benefit from selective serotonin reuptake inhibitor (SSRI) treatment in major depressive disorder (MDD) usually takes several weeks. Typically, a third of patients achieve
July 3, 2020
