Basic

Modafinil

Adjunctive Modafinil at Initiation of Treatment with a Selective Serotonin Reuptake Inhibitor Enhances the Degree and Onset of Therapeutic Effects in Patients with Major Depressive Disorder and Fatigue

ABSTRACT BACKGROUND: Benefit from selective serotonin reuptake inhibitor (SSRI) treatment in major depressive disorder (MDD) usually takes…

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February 20, 2023
Modafinil Review

Modafinil vs. Caffeine: Effects on Fatigue During Sleep Deprivation

ABSTRACT INTRODUCTION: The extent to which modafinil and caffeine reverse fatigue effects (defined as performance decrements with…

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February 2, 2023
Modafinil

Effect of Modafinil on Cerebral Blood Flow in Narcolepsy Patients

ABSTRACT BACKGROUND: To investigate the effects of modafinil on regional cerebral blood flow (rCBF) in narcolepsy, we…

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February 20, 2023
Modafinil antidepressant

Clinical Pharmacokinetic Profile of Modafinil

ABSTRACT Aodafinil is a unique wake-promoting agent for oral administration. Its pharmacological properties are distinct from those…

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February 20, 2023
Modafinil - Cocaine

Modafinil for the Treatment of Excessive Daytime Sleepiness in Parkinson’s Disease: A Case Report

ABSTRACT We report a 59 year old woman with levodopa responsive Parkinson’s disease who developed excessive daytime…

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February 2, 2023

Orexin Peptides Prevent Cataplexy and Improve Wakefulness in an Orexin Neuron-Ablated Model of Narcolepsy in Mice

ABSTRACT Narcolepsy-cataplexy is a neurological disorder associated with the inability to maintain wakefulness and abnormal intrusions of…

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February 2, 2023
Modafinil

A Commentary on the Neurobiology of the Hypocretin/Orexin System

ABSTRACT Hypocretins/orexins are rapidly emerging as functionally important neurotransmitters. Two related neuropeptides (Hcrt-1/OXA, Hcrt-2/OXB) encoded by the…

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February 20, 2023
Modafinil

Modafinil More Effectively Induces Wakefulness in Orexin-Null Mice Than in Wild-Type Littermates

ABSTRACT Narcolepsy-cataplexy, a disorder of excessive sleepiness and abnormalities of rapid eye movement (REM) sleep, results from…

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February 20, 2023

Dosing Regimen Effects of Modafinil for Improving Daytime Wakefulness in Patients With Narcolepsy

ABSTRACT SUMMARY: In a multicenter, randomized, double-blind study the authors compared the efficacy of modafinil 400 mg…

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February 2, 2023
Pharmacological

Pharmacological Aspects of Human and Canine Narcolepsy

ABSTRACT Narcolepsy-cataplexy is a disabling neurological disorder that affects 1/2000 individuals. The main clinical features of narcolepsy,…

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February 20, 2023