Tomas Thorne

Modafinil

An Open-Label Study of Adjunctive Modafinil in Patients with Sedation Related to Serotonergic Antidepressant Therapy

ABSTRACT OBJECTIVE: In patients with major depressive disorder (MDD), excessive sleepiness and fatigue not only are major…

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February 20, 2023
Depression-Like Deficits

Depression-Like Deficits in Rats Improved by Subchronic Modafinil

ABSTRACT RATIONALE: Attentional and sensorimotor gating deficits in human depression are observed as residual symptoms irrespective of…

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February 20, 2023

Efficacy and Safety of Modafinil Film-Coated Tablets in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder: Results of a Randomized, Double-Blind, Placebo-Controlled, Flexible-Dose Study

ABSTRACT OBJECTIVE: Modafinil, which is structurally and pharmacologically different from other agents that are used for the…

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February 2, 2023
Retrospective Review of Modafinil

Retrospective Review of Modafinil Use for Cerebral Palsy

ABSTRACT A retrospective review was undertaken at Texas Tech University Health Sciences Center regarding the use of…

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February 20, 2023
Modafinil - Serotonin

Amplification of Cortical Serotonin Release: a Further Neurochemical Action of the Vigilance-Promoting Drug Modafinil

ABSTRACT The present in vitro and in vivo studies examined the effects of modafinil on serotonergic transmission…

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February 2, 2023
Armodafninil

Armodafinil, the R-Enantiomer of Modafinil: Wake-Promoting Effects and Pharmacokinetic Profile in the Rat

ABSTRACT Modafinil reduces the excessive sleepiness associated with narcolepsy, obstructive sleep apnea/hypopnea syndrome, and shift work sleep…

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February 2, 2023
Neuroprotective Effects of Modafinil

Neuroprotective Effects of Modafinil in a Marmoset Parkinson Model: Behavioral and Neurochemical Aspects

ABSTRACT The vigilance-enhancing agent modafinil has neuroprotective properties: it prevents striatal ischemic injury, nigrostriatal pathway deterioration after…

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February 20, 2023

Modafinil Affects Mood, But Not Cognitive Function, in Healthy Young Volunteers

ABSTRACT Modafinil is a selective wakefulness-promoting agent with beneficial effects in narcolepsy and conditions of sleep deprivation….

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February 2, 2023
Pharmacokinetics and Tolerability of Modafinil

Steady-State Pharmacokinetics and Tolerability of Modafinil Given Alone or in Combination with Methylphenidate in Healthy Volunteers

ABSTRACT The potential for a pharmacokinetic (PK) drug-drug interaction between modafinil and methylphenidate, each at steady state,…

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February 20, 2023
Modafinil

Steady-State Pharmacokinetics and Tolerability of Modafinil Administered Alone or in Combination with Dextroamphetamine in Healthy Volunteers

ABSTRACT The potential for a drug-drug interaction between modafinil and dextroamphetamine, each at steady state, was investigated…

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February 2, 2023