Basic

Armodafinil

The Efficacy and Safety of Armodafinil as Treatment for Adults with Excessive Sleepiness Associated with Narcolepsy

ABSTRACT OBJECTIVE: This study assessed the efficacy and safety of armodafinil, the longer half-life enantiomer of modafinil,…

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February 2, 2023

Systemic and Nasal Delivery of Orexin-A (Hypocretin-1) Reduces the Effects of Sleep Deprivation on Cognitive Performance in Nonhuman Primates

ABSTRACT Hypocretin-1 (orexin-A) was administered to sleep-deprived (30–36 h) rhesus monkeys immediately preceding testing on a multi-image…

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February 2, 2023
FDA Warning Letter

FDA Warning Letter

Dear Mr. Kirsch: This letter objects to Cephalon Inc’s (Cephalon) dissemination of false or misleading promotional materials1 for…

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February 20, 2023
A Double-Blind, Placebo-Controlled

A Double-Blind, Placebo-Controlled Investigation of the Efficacy of Modafinil for Sustaining the Alertness and Performance of Aviators: a Helicopter Simulator Study

ABSTRACT RATIONALE: In 1998, the FDA approved modafinil for treating excessive daytime sleepiness in narcoleptics, and this…

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February 20, 2023

Wake-Promoting and Sleep-Suppressing Actions of Hypocretin (Orexin): Basal Forebrain Sites of Action

ABSTRACT The hypocretins (orexins) are a newly identified peptide family comprised of two peptides, hypocretin-1 and hypocretin-2….

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February 2, 2023

Effects of Modafinil on Working Memory Processes in Humans

ABSTRACT RATIONALE: Modafinil is a well-tolerated psychostimulant drug with low addictive potential that is used to treat…

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February 2, 2023

Modafinil : A Review of Its Use in Excessive Sleepiness Associated with Obstructive Sleep Apnoea/Hypopnoea Syndrome and Shift Work Sleep Disorder

ABSTRACT Modafinil (Provigil((R))) is a wake-promoting agent that is pharmacologically distinct from CNS stimulants, such as amfetamine,…

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February 2, 2023

Pills Provide Brain Boost for Academics

Some academics use ‘smart drugs’ to sharpen their performance. Tony Tysome explores the issues Feeling under intense…

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February 2, 2023

Central Alpha 1-Adrenergic Stimulation in Relation to the Behaviour Stimulating Effect of Modafinil; Studies with Experimental Animals

ABSTRACT Single administration of the new drug modafinil was followed by an increase in locomotor activity in…

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February 2, 2023